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From 1978 through 1993(average of 10.7 years),there were 386 events(201 in men,29%fatal;185 in women,42%fatal).By multivariate proportional hazards life-table regression analysis,serum cholesterol level below the sex- specific 10th percentile(<4.62 mmol/L[178 mg/dL]in men),compared with higher cholesterol level,was associated with a significantly increased risk of intracerebral hemorrhage in men aged 65 years or older(relative risk,2.7;95%confidence interval,1.4 to 5.0).An excess risk was also observed among elderly women at the lowest cholesterol range,but a chance finding could not be ruled out.No relationship was seen among men or women aged 40 to 64,and no statistical interaction of low serum cholesterol with hypertension was found in either sex.In these data,the association between low serum cholesterol level and intracerebral hemorrhage was confined to elderly men. |
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